Human fascioliasis in Egyptian children: successful treatment with triclabendazole
نویسندگان
چکیده
منابع مشابه
Human fascioliasis: clinical features and diagnostic difficulties in Egyptian children.
Human fascioliasis (HF) has been reported in children worldwide and occasionally from Egypt. In the past 7 years we diagnosed 16 children aged 3.5-11 years (mean age: 6.5 years), 13 of them were boys, as HF. They were referred to Cairo University, Paediatric Hospital (CUPH), with pyrexia of undetermined origin (PUO) and abdominal pain. Diagnosis was based on high peripheral blood eosinophilia (...
متن کاملChanges in Hepatic Phase-I and -II Drug-metabolizing Enzymes and Antioxidant Capacity in Egyptian Ovine Fascioliasis Treated with Triclabendazole
Sheep experimentally infected with the Egyptian strain of Fasciola were used to study the influence of infection on the activities of some drug-metabolizing enzymes and antioxidant capacity in the liver. Twentytwo sheep were randomly divided into a group of 12 animals (all subsequently infected with 150 metacercariae of Fasciola) and a group of ten (left uninfected, as normal controls). Three m...
متن کاملEvaluation of two doses of triclabendazole in treatment of patients with combined schistosomiasis and fascioliasis.
To determine the safety and efficacy of 2 consecutive doses of triclabendazole (TCBZ) in the treatment of Schistosoma mansoni infection in human cases infected with both S. mansoni and Fasciola sp., we conducted a field survey involving 6314 individuals from 15 villages. The overall prevalence of schistosomiasis alone was 15.8%, of fascioliasis alone 2.2%, and of combined infection 0.7%. Treatm...
متن کاملA randomized controlled pilot study of artesunate versus triclabendazole for human fascioliasis in central Vietnam.
Human fascioliasis caused by Fasciola hepatica or Fasciola gigantica is an increasing global problem. The mainstay of current treatment is triclabendazole, but resistance in animals has been described, and it is not available in many countries. The antimalarial artesunate has an excellent safety profile, and there is increasing evidence of its efficacy against other parasites both in vitro and ...
متن کاملCLINICAL TRIAL OF TRICLABENDAZOLE ON HUMAN FASCIOLIASIS: LONG TERM FOLLOW UP
Following an outbreak: of human fascioliasis in Gilan province of Iran in 1989, the benzimidazole derivative triclabendazole (TCBZ) was suggested as the drug of choice after finding out that routine drugs were not effective. Two studies were performed: a clinical trial (before/after type) in 1989 and a historical cohort (1989- 1995) to examine the efficacy of the drug. TCBZ was administere...
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ژورنال
عنوان ژورنال: Journal of Tropical Pediatrics
سال: 1999
ISSN: 0142-6338,1465-3664
DOI: 10.1093/tropej/45.3.135